Methods and systems for drug screening and computational modeling

摘要

A method for screening a test compound for potential efficacy in treatment of a disorder includes creating a first computer model representative of a volume of disease-afflicted neural tissue exposed to the test compound; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test compound has the potential to be effective in treating the disorder.