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Partial modulation via pulsed flow modulator for comprehensive two-dimensional liquid or gas chromatography with multiple modulation periods
Partial modulation via pulsed flow modulator for comprehensive two-dimensional liquid or gas chromatography with multiple modulation periods
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机译:通过脉冲流量调制器进行部分调制,可实现具有多个调制周期的全面二维液相色谱或气相色谱
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摘要
This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation with multiple secondary retention times. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The secondary retention time period at which the modulator cycles is variable among multiple secondary retention time periods to prevent loss of resolution with less complex and/or low boiling point compounds and to prevent loss of data with more complex and/or higher boiling point compounds. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.
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