Alternatively spliced isoform of mitotic centromere-associated kinesin (MCAK)

摘要

The present invention features a nucleic acid and a polypeptide encoding a novel splice variant isoform of mitotic centromere-associated kinesin (MCAK). The polynucleotide sequence of MCAKsv1 is provided by SEQ ID NO 2. The amino acid sequence for MCAKsv1 is provided by SEQ ID NO 3. The present invention also provides methods for using MCAKsv1 polynucleotide and protein to screen for compounds that bind to MCAKsv1 and to screen for compounds that bind to other kinesin isoform polypeptides but not to MCAKsv1.