;The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. ;This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections."/>
公开/公告号US2006014746A1
专利类型
公开/公告日2006-01-19
原文格式PDF
申请/专利权人 ALAN HUTCHISON;GEORGE MAYNARD;PAMELA ALBAUGH;LINGHONG XIE;JUN YUAN;SCOTT MITCHELL;VINOD SINGH;MANUKA GHOSH;GUIYING LI;NIAN LIU;
申请/专利号US20050214345
发明设计人 ALAN HUTCHISON;GEORGE MAYNARD;PAMELA ALBAUGH;LINGHONG XIE;JUN YUAN;SCOTT MITCHELL;VINOD SINGH;MANUKA GHOSH;GUIYING LI;NIAN LIU;
申请日2005-08-29
分类号C07D487/04;C07D471/02;A61K31/519;A61K31/503;A61K31/4745;
国家 US
入库时间 2022-08-21 21:45:14