Isolated T lymphocyte receptors specific for human autoantigens complexed with human MHC molecules and methods of making and using same

摘要

Isolated T cell receptors having binding specificity for a particular class of MHC polypeptide in complex with autoantigens are provided. Methods of producing the isolated T cell receptors and methods of using the isolated T cell receptors in screening assays, diagnostic assays and therapeutic applications for rheumatoid arthritis are also provided. Assay kits comprising the isolated T cell receptors are further provided.