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Method for the identification of extracellular domains of Epstein Barr Virus (EBV) tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
Method for the identification of extracellular domains of Epstein Barr Virus (EBV) tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
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机译:鉴定爱泼斯坦巴尔病毒(EBV)肿瘤相关潜伏膜蛋白胞外域的方法以及与之反应的抗体试剂的选择
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摘要
Described are a method for the identification of extracellular epitopes of Epstein Barr virus (EBV) encoded membrane proteins, expressed on the outer cell surface of EBV-transformed mammalian cells, methods fo rthe selection and preparation of antibody reagents specific for the said epitopes, as well as peptides, including extracellular domains of Epstein Barr Virus encoded tumour cell associated membrane proteins, the use of said peptide for immunization and therapeutic vaccination to induce antibodies and T-cells reactive with said domains, the use of said antibody reagents for the production of targeting cells, tumour cell purging and as diagnostic for and medicament against EBV-mediated malignant cell growth.
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