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Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands
Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands
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机译:筛选抗配体文库以鉴定对差异和不频繁表达的配体具有特异性的抗配体的方法
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摘要
The present invention relates to screening methods and, in particular, to methods of screening anti-ligands libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
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