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Composition and methods for inhibiting expression of hypoxia-inducible genes
Composition and methods for inhibiting expression of hypoxia-inducible genes
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机译:抑制缺氧诱导基因表达的组合物和方法
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摘要
Methods are provided for interfering with a hypoxia-mediated transcriptional pathway using an agent that binds to a hypoxia response element and inhibits transcription of a hypoxia inducible gene associated therewith. Also provided are methods of treating a patient with a solid tumors, and compositions useful for treating a patient having solid tumors, including, for example, by administering an agent that binds to a hypoxia response element in a cell. Agents for the methods of the invention are provided including compositions comprising a pyrrole imidazole polyamide or a pharmaceutically acceptable salt or complex thereof.
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