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Synthesis procedure for imidazolyl carbinol derivatives such as biphenylimidazolyl-(1)-phenylmethane
Synthesis procedure for imidazolyl carbinol derivatives such as biphenylimidazolyl-(1)-phenylmethane
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机译:咪唑基甲醇衍生物如联苯基咪唑基-(1)-苯基甲烷的合成方法
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摘要
A synthesis procedure for the manufacture of byphenylimidazolyl-(1)-phenylmethane involves the reduction of 4-phenyl-benzophenone and subsequent reaction of biphenyl-phenyl-carbinol with imidazole. In a preferred form, there are two synthesis steps, the first step being the reduction of 4-phenyl-benzophenone to biphenyl-phenyl-carbinol being with sodium borohydride in the presence of alumina, and the second step being the reaction between biphenyl-phenyl-carbinol and imidazole assisted by microwaves, in the absence of any organic or inorganic solvents, obtaining a yield between 70 to 74% of pure product in a total reaction time of no more than three hours.
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