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Artemisinins with improved stability and bioavailability for therapeutic drug development and application
Artemisinins with improved stability and bioavailability for therapeutic drug development and application
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机译:青蒿素具有更高的稳定性和生物利用度,可用于治疗药物的开发和应用
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摘要
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.
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