DNA molecules encoding L-glutamate-gated chloride channels from Schistocerca americana

摘要

The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Schistocerca americana (grasshopper) glutamate-gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding S. americana glutamate-gated chloride channels, substantially purified forms of associated S. americana glutamate-gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Schistocerca americana glutamate-gated chloride channels, which will be useful as insecticides.