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Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
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机译:鉴定调节肝脂肪酶启动子的雌激素受体依赖性配体的方法
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摘要
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
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