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Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route

机译:通过吸入途径输送舒马曲坦,氟罗曲普坦或那拉曲普坦

摘要

The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a method aspect of the present invention, one of sumatriptan, frovatriptan, or naratriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising sumatriptan, frovatriptan, or naratriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route is provided which comprises: a) a thin coating of a sumatriptan, frovatriptan, or naratriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
机译:本发明涉及通过吸入途径递送抗偏头痛化合物。具体地,本发明涉及用于吸入疗法的包含舒马曲坦,弗罗曲普坦或那拉曲普坦的气雾剂。在本发明的方法方面,舒马曲坦,弗罗曲坦或那拉曲普坦中的一种通过吸入途径施用于患者。该方法包括:a)加热包含舒马曲坦,frovatriptan或naratriptan的组合物以形成蒸气; b)使蒸气冷却,从而与少于5%的药物降解产物形成冷凝气溶胶。在本发明的试剂盒方面,提供了一种用于通过吸入途径递送舒马曲坦,夫罗曲普坦或那拉曲普坦的试剂盒,其包括:a)舒马曲坦,弗罗曲普坦或那拉曲普坦组合物的薄涂层; b)一种用于将所述薄涂层分配为冷凝气溶胶的装置。

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