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Pharmaceutically active lipid based formulation of irinotecan
Pharmaceutically active lipid based formulation of irinotecan
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机译:伊立替康的基于药物活性脂质的制剂
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摘要
Delivering therapeutic amounts of irinotecan remains limited due to its highly water insoluble properties. This invention overcomes this limitation by presenting a novel method of preparing liposomal irinotecan by first inactivating irinotecan prior to liposome formation and then subsequently activating the irinotecan by lowering the pH of the lipid composition to an acidic pH of less than about 3.5, such as between 1.5-3.0 or about 2.
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