Process for preparing Pharmaceutical compositions containing alendronate together with pharmaceutically acceptable excipients by Dry granulation with a higher Fluidity, composition obtained by Said method and use of this composition for preparing Medicine

摘要

Process for preparing Pharmaceutical compositions containing monosodium alendronate Trihydrate by means of Dry granulation process, whose composition obtained by this process shows a higher Fluidity and solid oral form, Achieving a size smaller. Also requests the medical use of those compositions and the compositions obtained by this process.Said process includes the following steps: Mixing of 10 to 50% of the assets with 50% to 90% of the filling Agent With 0.5 to 5% of a disintegrant, a lubricant and sliding, Compacting the Mixture with a Machine suitable to compress, fragmenting the Compacted product through a m Olino conventionalComplete the remaining part of the added Ingredients to granule resulting from grinding and mixing to obtain the final Particle, and finally make the final composition. Method of treatment.