Cross-linked Hyaluronic acid Soluble in water, its preparation Method, implant containing the cross-linked Hyaluronic acid and its use

摘要

This aims to presents a cross-linked Hyaluronic acid solubility in water and is capable of being obtained by a preparation method comprising contacting an aqueous medium, at least one Hyaluronic acid or its Salts,And at least a cross-linking Agent comprising at least one oligopu00e9ptido or polypeptide with at least two, preferably at least five lysine units, wherein Said contacting is carried out in the presence of at least a coupling Agent, water soluble and so A Catalyst.This also refers to a Set containing the cross-linked Hyaluronic acid and their use in human or Veterinary Medicine, in particular in reconstructive surgery and / or Aesthetics.