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Process for the preparation of combination pharmaceutical formulations using supercritical fluids
Process for the preparation of combination pharmaceutical formulations using supercritical fluids
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机译:使用超临界流体制备组合药物制剂的方法
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摘要
"PROCESS FOR PREPARING PHARMACEUTICAL COMBINATION FORMULATIONS USING SUPERCRITIC FLUIDS". The invention is directed to a process for the preparation of a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) contacting two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to produce a powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infectious agents or two anti-cancer agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active pharmaceutical ingredients with a co-solvent to form a solution; (b) contacting the solution with a supercritical fluid; and (c) recovering the precipitate in a powder form.
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