methods of producing an antibody to a polypeptide, antibody or antibody fragment, method of reducing or inhibiting il-22-induced or il-20-induced proliferation or differentiation of hematopoietic cells and hematopoietic cell progenitors, use of an antibody, a composition of an antibody or antibody fragment, use of an il-22 or il-20 antagonist, use of an il-22ra antagonist

摘要

"METHODS OF PRODUCING AN ANTIBODY FOR AN ANTIBODY POLYPEPTIDE, ANTIBODY OR FRAGMENT, METHOD FOR REDUCING OR INHIBITING IL-22-INDUCED OR DIFFERENTIATION OF HEMOPATHYELE CELLULAELE CELLULES, OF AN ANTIBODY COMPOSITION OR ANTIBODY FRAGMENT, USE OF AN IL-22 OR IL-20 ANTAGONIST, USE OF AN IL-22RA ANTAGONIST ". The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using these antibodies and binding partners.