heterologous fusion protein, polynucleotide, vector, host cell, process for producing a heterologous fusion protein, methods for treating an insulin-independent diabetes mellitus patient and for inducing weight loss in an overweight patient, and protein use heterologous fusion

摘要

"HYPEROLOGICAL FUSION PROTEIN, POLYNUCLEOTIDE, VECTOR, HOST CELL, PROCESS PAPA TO PRODUCE A HYPEROLOGICAL FUSION PROTEIN, METHODS TO TREAT A PATIENT WITH DIABETIC MELT INDEPENDENT AND INDEPENDENT INDOUS OF THE INSULATED INPUT OF THE INSULA Heterologous Fusion Protein ". The invention provides specific GLP-1 analogs fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half life, decreased immunogenicity, and reduced effector activity. Fusion proteins are useful in the treatment of diabetes, obesity, irritable bowel syndrome, and other conditions that would benefit from lowering plasma glucose, inhibiting intestinal and / or gastric motility, and inhibiting bowel emptying and / or gastric acid, or by inhibiting food intake.