Malonamide derivatives compounds of gamma secretase Inhibitors, its Synthesis method and Pharmaceutical compositions containing them

摘要

1. - (CH2) 1,2 -, the compounds in the comprehensive calculation method are links;-CH (CH3) -o en It is a cyclic ring, chosen from the group consisting of phenyl, pyridinyl, furanyl, benzo [b] thiophenyl, tetrahydronaphthyl, indanyl, 2,2-dimethyl- [1,3] dioxolanyl and tetrahydrofuranyl; R1 and R1AND # 39 are same or different and are hydrogen, lower alkyl, halogen, benzyl or lower alkenyl; (R2) 1,2,3 irrespective of its occurrence is hydrogen, hydrozi, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R3 - is phenyl or benzyl, which are unsubstituted or substituted by one or two substituents, chosen from the group consisting of halogen and cyano, or is-lower alkyl, - two hydrogen atoms, - (CH2) 1,2-S-lower alkyl, - (CH2) 1,2-cycloalkyl,-(CH 2) 1, 2-OH, - ch2och2-phenyl, or R4 group is low alcoxi, - mono-o diklamino, - n (CH3) (CH2) 1, 2-C = ch, or a single group.Two or three cycles, not replaced or replaced by other R5 to R10, can be linked by - n (CH3) (CH2) 0.1.2.