Azepin dibenzo derivative compounds and benzoazepin substituted gamma secretase Inhibitors, its Synthesis process and Pharmaceutical compositions containing them

摘要

1 - Compuestos de f rmula general en donde R1 es - (CHR) q-arilo o - (CHR) q-heteroarilo que est n sin sustituir o mono di- o tri-sustituidos por alquilo inferior alcoxilo inferior CF3 o hal geno o es or is - (CH2) n-CR2-CF3, where the two radicals R together with the carbon atom form a cycloalkyl ring; R´ is hydrogen or lower alkyl; n is 1, 2 or 3; m is 0 or 1 ; p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2 or 3; R2 is hydrogen or lower alkyl; R3 is hydrogen, lower alkyl, -CH2CF2CF3, CH2CF3, (CH2) 2CF3 , CF3, CHF2, CH2F o is aryl, optionally mono, di or tri-substituted by halogen, or is - (CH2) nNR5R6, where R5 and R6 are independently of each other hydrogen or lower alkyl; R4 is one of the following groups where R7 is hydrogen, lower alkyl, - (CH2) n-CF3 or - (CH2) n-cycloalkyl; R8 is hydrogen, lower alkyl, -C (O) -phenyl,-C (O) -lower alkyl, -C (O) O- (CH2) n-cycloalkyl, -C (O) O- (CH2) n-lower alkyl, -C (O) NH- (CH2) n- lower alkyl or -C (O) NH- (CH2) n-cycloalkyl; R9 is hydrogen, lower alkyl, - (CH2) n-cycloalkyl or - (CH2) n-CF3; and to pharmaceutically acceptable acid addition salts, optically enantiomers cigars, racemates or diastereomeric mixtures thereof.