Inhibitors of factor of Macrophage Migration inhibitor and Method for identification

摘要

1. - structural compounds: or stereoisomers, by-products or salts with acceptable drugs, wherein X is oxygen or sulfur; Z is - ch2o-c (= O) -;N is 0, 1 or 2, but n is O, Z is - C (= O);;R1 is selected from the group consisting of hydrogen, asphalt, alternative asphalt, arilo, alternative arilo, arilalquilo, alternative acilalquilo, alternative acilalquilo, alternative acilalilo, alternative acilario, heterocycle, alternative isocyclopropyl compound or isocyclopropyl compound, n (CH2) x (where x is 2-4); "R" and "R" are independent of a group consisting of hydrogen, asphalt, alternative asphalt, asphalt, arilalquilo, alternative arilalquilo, aclalquilo, alternative acilaliquilo, alternative anhydrides, alternative heterocycles, alternative heterocycles, alternative heterocycles or alternative heterocycles and diquilo;R2 and R3 are selected independently from halogen, R5, R5, SR5 or - nr5r6 groups; R4 is selected from groups consisting of - ch2r7, - C (= O) nr5r6, - C (= O) or7, - C (= O) R7 and R8, (= O) or7;The selection of R5 and R6 does not consider the group composed of hydrogen, tar, alternative asphalt, arilo, alternative arilo, arilalquilo, alternative arilalquilo, alternative arilo, acilalquilo, alternative acilalquilo, alternative acilario, alternative acilario, heterocycle, alternative.