INHIBITORS OF THE INHIBITOR FACTOR OF THE MIGRATION OF MACROPHAGES AND METHODS FOR IDENTIFICATION.

摘要

A compound with structure: ** (See formula) ** or a stereoisomer, or a pharmaceutically acceptable salt thereof, where: X is oxygen; Y is selected from the group consisting of -NO2, -C (= O) R5, -C (= O) OR5 and -C (= O) NR5R6; Z is -CH2-; n is 1; R1 is selected from the group consisting of hydrogen, C1-10 alkyl, C1-10 aryl alkyl, phenyl, naphthyl, 5-7 membered monocyclic heterocycle and 7 to 14 membered polycyclic heterocycle, where R1 is substituted or not with at least a substituent selected from the group consisting of halogen, alkoxy, alkylamino, dialkylamino and keto; R2 and R3 are independently selected from the group consisting of halogen, hydrogen and C1-10 alkyl; R4 is selected from the group consisting of -CH2R7, -C (= O) NR5R6, -C (= O) OR7 and -C (= O) R7; each R5 and R6 is independently selected from the group consisting of hydrogen, C1-10 alkyl and C1-10 aryl alkyl; or R5 and R6 together with a nitrogen atom to which they are attached form a 5 to 7 membered monocyclic heterocycle or a 7 to 14 membered polycyclic heterocycle, where R5 and R6 are independently substituted or not with at least one substituent selected from the group formed by halogen, alkoxy, alkylamino, dialkylamino and keto; R7 is selected from the group consisting of C1-10 alkyl, C1-10 aryl alkyl, phenyl, naphthyl, 5-7 membered monocyclic heterocycle and 7 to 14 membered polycyclic heterocycle, where R7 is substituted or not with at least one substituent selected from the group consisting of halogen, alkoxy, alkylamino, dialkylamino and keto.