Process for Preparation of 2- (4-alkyl-1-piperazinyl) -benzaldehyde and -benzylidene compounds by nucleophilic aromatic substitution of 2-fluorobenzaldehyde with 4-alkyl-1-peperazine in water as solvent

摘要

A process for the preparation of a compound of formula I: CHEM wherein R1 is (C1-C6) alkyl; comprising the step of allowing a compound of formula III: CHEM to react with a compound of formula IV: CHEM in the presence of a metal carbonate, characterized by the use of water as solvent. Further, a process for the preparation of a compound of formula II: CHEM involving the above mentioned process.d