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Combination therapy with angiotensin converting enzyme inhibitor and epoxy steroidal aldosterone antagonist to treat cardiovascular disease
Combination therapy with angiotensin converting enzyme inhibitor and epoxy steroidal aldosterone antagonist to treat cardiovascular disease
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机译:血管紧张素转化酶抑制剂和环氧类固醇醛固酮拮抗剂联合治疗心血管疾病
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摘要
Combinations of an ACE inhibitor and an epoxy-steroidal aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using epoxy-steroidal-type aldosterone receptor antagonist compounds, such as eplerenone, in combination with an angiotensin converting enzyme inhibitor. This co-therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.
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