Recognition of tumor vasculature targeted using the Antibody L19 against Fibronectin radiolabelled ed - B

摘要

A specific element that binds to human beings. The specific binding element is labeled with isotopes selected from a group consisting of 76Br, 77br, 123I, 124I, 131I and 211At, and includes an antigen binding site, including VH antibody and VL antibody domains, The VH domain consists of VH CDR1, VH CDR2 and VH CDR3. VH CDR3 is L19 VH CDR3 with SEQ ID No.3, VH CDR1 is L19 VH CDR1 with SEQ ID No.1, and VH CDR2 is L19 VH CDR2 with SEQ ID No.1.y donde el dominio de anticuerpo VL se selecciona opcionalmente del grupo formado por el dominio VL de L19 y un dominio VL que comprende una VL CDR1 una VL CDR2 y una VL CDR3 donde la VL CDR3 es la L19 VL CDR3 de la SEQ ID N 6 The specific binding elements include a microimmunoglobulin, a VH antibody domain and a VL antibody domain combined with es2-ch4, which are oxidized or contain a complete IgG1 antibody molecule, and the method and use of the specific binding element.