5-OXO AND 5-THIO DERIVATIVES OF 5H-INDENO' 1,2-BIPYRIDINE WITH ADENOSINE A2A RECEPTOR BINDING AND PHOSPHODIESTERASE INHIBITING ACTIVITY FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND INFLAMMATION RELATED DISEASES

摘要

This invention provides novel arylindenopyridines of the formula: , and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.