5-OXO AND 5-THIO DERIVATIVES OF 5H-INDENO'1,2-BIPYRIDINE WITH ADENOSINE A2A RECEPTOR BINDING AND PHOSPHODIESTERASE INHIBITING ACTIVITY FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND INFLAMMATION RELATED DISEASES.

摘要

This invention provides novel arylindenopyridines of formula: (I), and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.