PROCESS FOR THE PREPARATION OF NALBUPHINE HAVING NOT MORE THEN 1 LEVELS OF BETA-EPIMER

摘要

PCT No. PCT/US95/06097 Sec. 371 Date Nov. 26, 1996 Sec. 102(e) Date Nov. 26, 1996 PCT Filed May 16, 1995 PCT Pub. No. WO95/32973 PCT Pub. Date Dec. 7, 1995A process is described for the synthesis of nalbuphine. The process results in a product having very low levels of the undesirable beta -epimer. The process is a five-step synthesis that begins with a compound such as an N,O3-bis (alkoxycarbonyl) -14-hydroxynormorphinone.