PHARMACEUTICAL COMPOSITIONS COMPRISING NON-TOXIC NSAID FOR USE IN RETARDING OR PREVENTING TRANSFORMATION OF COLONIC ADENOMAS TO A COLONIC ADENOCARCINOMA

摘要

This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.