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ANTI-INFLAMMATORY PEPTIDES DERIVED FROM C-REACTIVE PROTEIN AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
ANTI-INFLAMMATORY PEPTIDES DERIVED FROM C-REACTIVE PROTEIN AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
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机译:从C-反应蛋白和组成它们的药物成分衍生的抗炎肽
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摘要
A peptide corresponding to positions 62-71 of the sequence of human C-reactive protein (CRP) of the formula: Glu62-Ile-Leu-Ile-Phe-Trp-Ser-Lys-Asp-Ile71 and modifications thereof obtained by substitution, deletion, or addition of amino acids, amidation of the C-terminal or acylation of the N-terminal, are capable of inhibiting in vitro the enzymatic activity of human Leukocyte Elastase (hLE) and/or of human Cathepsin G (hCG) and can be used for the treatment of chronic inflammation conditions such as rheumatoid arthritis, pulmonary emphysema, cystic fibrosis, bronchitis, asthma and acute respiratory distress syndrome.
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