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METHOD FOR THE PRODUCTION OF RECOMBINANT FACTOR VIII, A RECOMBINANT FACTOR VIII PRODUCED BY THE METHOD, AND A CELL CULTURE MEDIUM FOR USE IN THE METHOD
METHOD FOR THE PRODUCTION OF RECOMBINANT FACTOR VIII, A RECOMBINANT FACTOR VIII PRODUCED BY THE METHOD, AND A CELL CULTURE MEDIUM FOR USE IN THE METHOD
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机译:重组因子VIII的生产方法,通过该方法生产的重组因子VIII以及用于该方法的细胞培养介质
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摘要
Recombinant Factor VIII can be produced in relatively large quantities on a continuous basis from mammalian cells in the absence of any animal- derived proteins such as albumin by culturing the cells in a protein free medium supplemented with polyol copolymers, preferably in the presence of trace metals such as copper. In very preferred embodiments, the medium includes a polyglycol known as Pluronic F-68, copper sulfate, ferrous sulfate/EDTA complex, and salts of trace metals such as manganese, molybdenum, silicon, lithium and chromium.
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