COMPOUNDS WHICH ELEVATE PYRUVATE DEHYDROGENASE (PDH) ACTIVITY, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF MEDICAMENTS FOR USE IN THE ELEVATION OF PDH ACTIVITY IN WARM-BLOODED ANIMALS

摘要

The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; RSUP1 /SUPis an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; RSUP2 /SUPand RSUP3 /SUPare as defined within; RSUP4 /SUPis hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described