NOVEL POLYMORPHIC FORMS OF IMATINIB MESYLATE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

摘要

The present invention relates to novel crystalline polymorphic Form I & Form n of , imatinib mesylate and methods for their preparation. The Form I is prepared by slurrying I imatinib mesylate X 2 RUSROPRUSKLF)RUPLQ chloroform and water with heating and distilling off water followed by filtration. Form II is prepared by lyophilizing an aqueous solution of polymorph (X 2 RU The invention also relates to pharmaceutical composition containing the new Forms useful for the treatment of chronic myelogenous leukemia and accelerated stress conditions for the treatment of chronic myelogenous leukemia and accelerated stress conditions.