USE OF GENETIC POLYMORPHISMS TO PREDICT DRUG-INDUCED HEPATOTOXICITY.

摘要

ILIA or a gene located near ILIA on chromosome 2q14 may contribute to hepatotoxicity, as measured by increased serum levels of aspartate transaminase, during N-benzoyl-staurosporine treatment for macular edema. Accordingly, genetic polymorphisms in the ILIA gene are useful as biomarkers for predicting staurosporine derivative-mediated hepatotoxicity.