The invention discloses a kind of methods for aiming at maytansinoid to a selected cell population, method, it include contact a cell colony or it is doubtful comprising with a unit-shellac bond maytansinoid cognate selected cell population tissue, wherein one or more maytansinoids are covalently linked to unit-shellac bond via a cleavable linker, and unit-shellac bond is tied to the unit of selected cell population.
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