Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivative

摘要

Polymeric compositions capable of forming stable micelles in an aqueous solution are disclosed, which comprise an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition. The polymeric compositions may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.