Heterocyclic substituted Indan derivatives as antagonists of dopamine D2 Receptors and serotonin 2a

摘要

Refers to substituted Heterocyclic indan Derivatives of formula Ia where J is s, so, SO2, CH2, where NR10 R10 is H, alkyl of C1 - C6 C (= o) c1-c6 alkyl, - C (= o) or alqulo C1 - C6; M is CH, CH N; g n; M is 1 to 6; X is o, NR1, where R3 is R10, C (= o), Choh, chor3, among others; r1 is H, Halo, cyano, C1 - C6 alkyl substituted with one to three Fluorine Atoms.C1-c6 alkoxy optionally substituted with one to three Fluorine ATOMS, among other r1; R2 is under the condition that R2 cannot form a Heterocyclic ring is present when R1, R4 and R5 are h, Halo, cyano, aminoalquilo c1-c6 alkoxy, C1 - C6, R6, R7, among others; R8 and R9 are h, alkyl of C1 - C6, OPC Ionalmente replaced with one to three Fluorine Atoms; and when R11 is present is selected, orR13 NR13, which is defined as R10 (CH2) W, where W is 1 to 6; n is 1 to 3; Z is 1 to 3; R11 is H, alkyl of C1 - C6 C1 - C6 alkyl - SO2 -, among others.Preferred compounds are n {2 - [6 - (4 - (benzo [d] isotiazol ilpiperazin - 3 - 1 - il) ethyl] - 1 - indan il} acetamide; (S) - (+) - N - (5 - [2 - [4 - (benzo [d] - 3 - ilpiperazin isotiazol - 1 - il) ethyl] - 2 - indan il} acetamide; (R) - n {(-) - 5 - [2 - [4 - (benzo [d] isotiazol ilpiperazin - - 3 - 1 - il) ethyl] - 2 - indan il} propionamide; among others. It also relates to a Pharmaceutical Composition and a process for Preparation.These compounds are antagonists of dopamine D2 and serotonin 2a receptor (5HT2A) being useful in the treatment of Schizophrenia and other disorders of the CNS