Arilpiperazina sulfonamide derivatives as agonists of the receptors of growth hormone secretagogue (GHS)

摘要

Refers to arilpiperazina sulfonamide compounds of formula (i), wherein ar is aryl or heteroaryl, as tienilo, phenyl, naphthyl, among others, and is optionally substituted; single link, ch2ch2 or CH = CH2, CH; RB is H or alkyl (C1 - C6), RC is H or alkyl (Methyl; RD is C1 - C 6); re is H, alkyl, cycloalkyl (C1 - C6) (C3 and C6), coalquilo (C1 - C6) (C1 - C6), alkoxy, halogen, Oh,Trifluoromethyl or cyano and RF is H, alkyl, cycloalkyl (C1 - C6) (C1 - C6), alkoxy (C1 - C6), among others. Are preferred: N - [3 - (CIS - 3.5 - dimethyl - 1-piperazinyl) - 4 - (metiloxi) phenyl] - 5 - (2-pyridinyl) - 2 - [4 - (tienosulfonamida, 3-chloro-2 - cianofenil) oxy] - N - [3 - (CIS - 3.5 - dimethyl - 1-piperazinyl) - 4 - (metiloxi) phenyl] benzenesulfonamide, among others.It also relates to a Pharmaceutical Composition and a process for Preparation. These compounds are Selective agonists of the growth hormone secretagogues (GHS) and are useful in the treatment of cachexia, Sarcopenia, osteoporosis, arthritis, Growth Hormone deficiency, Metabolic disturbances, sleep and heart failure