Derivatives of 2 - (4 - (4 - (3, 5 - bis - (trifluoromethyl benzyl) - 2 - methyl - 2h-tetrazol-5-yl) - amino - 2 - ethyl - 2 - trifluoromethyl - 3,4-dihydro - 2H - quinoline - 1 - carbonyl} - cyclohexyl) - acetamide as CETP inhibitors

摘要

Refers to compounds of 4 - amino - 2 - 1,2,3,4 - Tetrahidroquinolina of formula (i) wherein R1 is and W - O - W and - and or; where W is carbonyl; and Z is (C1 - C10) or alkyl, optionally substituted amino oxo Halo, amido, alkoxy (C1 - C6), carboxy, among others; Z is a ring, such as Cyclohexyl substituted, optionally with amido or carboxy alkyl (C1 - C6)Among others, R2 is alkyl (c1-c4) or cycloalkyl (C1 - C6); R4 is V, - cooalquilo (c1-c4), among others, where V is tetrazolilo, oxadiazolilo, among others, optionally substituted; R5, R6, R7 and R8 are independently h, halogen, alkyl, cyano, (c1-c4) or alkoxy optionally substituted with has Logeno.Are preferred: acid ethyl ester ({4 - [4 - (3,5-bis - (trifluoromethyl) - benzyl) - 2 - methyl - 2h-tetrazol-5-yl) - amino] - 2 - ethyl - 2 - trifluoromethyl - 3,4-dihydro - 2H - quinoline - 1 - carbonyl) cyclohexyl] Acid, (2R, 4S) - {{2 - (4 - [4 - (3,5-bis - (trifluoromethyl) - benzyl) - 2 - methyl - 2h-tetrazol-5-yl) - amino] - 2 - ethyl - 4 - trifluoromet Il - 3,4-dihydro - 2H - quinoline - 1 - carbonyl) - cyclohexyl) - acetamide, among others.It also relates to a Pharmaceutical composition or kit can also understand another Agent as an inhibitor of HMG CoA reductase or a Modulator of PPAR.These compounds are inhibitors of the colesterilico ester transfer protein (CETP), and are useful in the treatment of diseases exacerbated by low levels of HDL cholesterol and / or high levels of LDL and TG, such as atherosclerosis or Cardiovascular Diseases