Compounds of N - sulfonilaminofeniletil - 2 - substituted fenoxiacetamida

摘要

Refers to a compound of formula I wherein R1 is C1 - C6 alkyl; R2 is H, halogen, Hydroxy, alkoxy C1 - C6, among others; R3 is Halogen, alkyl of C1 - C6 alkyl (C1 - C6) - Uncle, among others; R4 is a Halogen, alkyl of C1 - C6 hydroxy alkoxy - C1 - C6, among others; R5 C1 - C6 is Halogen, alkyl, alkoxy C1 - C6 Among others, * indicates a Chiral Centre, a Salt or solvate thereof.Preferred compounds are 2 - (4 - tert - butyl - 3.5 - difluorufenoxi) - N - (1 - {3 - methyl - 4 - [(methylsulfonyl) amino] ethyl] phenyl) acetamide; 2 - (4 - tert - butyl - 3.5 - difluorofenoxi) - N - (1 - {3 - fluoro - [4 - (methylsulfonyl) ethyl) amino] phenyl] acetamide; 2 - (4 - tert - butyl - 3.5 - difluorofenoxi) - N - (1 - (4 - [(methylsulfonyl) amino] phenyl) ethyl) Acetamide; among others. Refers to a Pharmaceutical Composition and a preparation method.The compounds are antagonists vainilloide receptor 1 (Vr1) and are useful for the treatment of chronic pain, neuropathies, Sciatica, headache