Compounds and components of protein-based enzyme inhibitors

摘要

It refers to a formula compound (I), in which n is 0-4; R1 is h, C1-C4 (arilo C6-C10) - tar (C1-C4),Among other things, R2 is h, C1-C6 aspha R3 is h, C1-C6 aspha R4 is halogen, C1-C6 asphalt, C1-C6 alcoxyl, C1-C6 aspha R15 is the best 3-trifluoromotil-benzoil-amine. The most popular compounds are: acid 2 - (3-diethylmethylacrylonitrile) - thiazol-5-carboxy [2-methyl-5 - (3-trifluoromethyl-benzamide) - phenyl]; acid 2 - {6 - [4 - (2-hydroxy) - pyridine-1-phenyl] - 2-methylpyridine-4-nilamino} - sulfur-5-carboxyl [2-methyl-5 - (3-trifluoromethyl-phenyl) - toluenediol. 2 - (2-hydroxy-acetamide) - thiazol-5-carbohydrate {5 - [3 - (4-ethyl-pyridine-1-nil) - 5-trifluoromethyl-benzoic acid amine] - 2-methyl-phenyl} - amide;There are others He also mentioned a composer of pharmacology These compounds inhibit the activity of protein quinasa, such as Abelson thyroid kinase (ABL),Oncology thyroid hormone (bcr-abl),It is useful, among other things, in the treatment of leukemia, blood cells, scabies, thrombosis and abscesses