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USE OF BRADICARDIC SUBSTANCES IN THE TREATMENT OF MYOCARDIAL DISEASES ASSOCIATED WITH HYPERTROPHY AND NEW MEDICINAL COMBINATIONS
USE OF BRADICARDIC SUBSTANCES IN THE TREATMENT OF MYOCARDIAL DISEASES ASSOCIATED WITH HYPERTROPHY AND NEW MEDICINAL COMBINATIONS
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机译:B类物质在肥大和新药物合并症所致心肌病的治疗中的应用
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摘要
A medicament (A) for treating myocardial diseases associated with hypertrophy contains a bradycardic agent (I) and optionally another cardiac drug (II). ACTIVITY : Cardiant. In tests in a cat having severe hypertrophic cardiomyopathy, oral administration of cilobradine (Ia) twice daily at 0.3 mg/kg marked reduced the clinical symptoms (e.g. by reducing pain and normalizing the ECG) and also caused regression of the myocardial hypertrophy after 1 and 2 years. MECHANISM OF ACTION : Calcium ion channel blocker; beta -receptor blocker; i f channel blocker.
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