Use of a metabolic derivative of loratadine for the manufacture of a medicament for treatment of allergic rhinitis and other disorders

摘要

The use of a metabolic derivative of loratadine, this derivative is 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H- benzo[5,6]cyclohepta[1,2-b] pyridine (DCL) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treatment of allergic rhinitis, allergic asthma, retinopathy or other small vessel disorders associated with diabetes mellitus, urticaria and symptomatic dermographism in a human while avoiding the concomitant liability of adverse side-effects associated with the administration of non-sedating antihistamines and while avoiding cardiac arrhythmias or tumor promotion.