Process of preparation and purification of tramadol and tramadol hydrochloride

摘要

Described is the process of preparation and purification of tramadol and tramadol hydrochloride, which can be used as an analgesic. Tramadol is prepared by reaction 3-methoxyphenylmagnesium halide with 2-dimethylaminomethylcyklohexanone in tetrahydrofurane,the developed complex is hydrolyzated and the blend of (RR,SS)-tramadol, (RS,SR)-tramadol, 6-olefin and/or 1-olefin is isolated, than is epimerizated at the present of organic acid and after that, the blend is alkalized and freed based are extracted in organic solvent and in such a way isolated tramadol is treated in a reaction with hydrogen chloride in the blend of ethanol and ether to (RR,SS)-tramadol hydrochloride.