A DOUBLE CAPSULE FOR THE ADMINISTRATION OF ACTIVE PRINCIPLES IN MULTIPLE THERAPIES

摘要

A PHARMACEUTICAL DOSAGE FORM PARTICULARLY SUITABLE FOR THE ADMINISTRATION OF ACTIVE PRINCIPLES IN MULTIPLE THERAPIES IS DISCLOSED. THE PHARMACEUTICAL DOSAGE FORM IS A DOUBLE CAPSULE WHEREIN AN INTERNAL CAPSULE IS PLACED INSIDE AN EXTERNAL ONE. EACH INTERNAL AND EXTERNAL CAPSULE INCLUDES ONE OR MORE ACTIVE PRINCIPLES. THE DOUBLE CAPSULE ACCORDING TO THE INVENTION IS PREFERABLY USE IN TRIPLE OR QUADRUPLE THERAPIES AGAINST THE MICROORGANISMS HELICOBACTER PYLORI. ADVANTAGES OF THIS PHARMACEUTICAL DOSAGE FORM CONSIST IN PROVIDING A SIMPLE POSOLOGY FOR ADMINISTRATION TWO AND MORE ACTIVE PRINCIPLES, ALLOWING THE ACTIVE PRINCIPLES TO ACTIVATE AT THE RIGHT INTERVALS OF TIME AND IN THE PRE-ESTABLISHED QUANTITIES, AND PREVENTING INTERACTIONS BETWEEN ACTIVE PRINCIPLES. IN A PREFERRED EMBODIMENT OF THE INVENTION, THE PHARMACEUTICAL DOSAGE FORM HAS AN EXTERNAL CAPSULE CONTAINING BISMUTH SUBCITRATE AND METRONIDAZOLE, AND AN INTERNAL CAPSULE CONTAINING TETRACYCLINE AND OPTIONALLY OMEPRAZOLE, WHICH IS USED IN A THERAPY FOR ERADICATION OF HELICOBACTER PYLORI.