METHOD OF DNA SEQUENCE REPRESENTATION BY USING DNA SURFACE CHARGE PATTERNS AND ITS APPLICATION TO IDENTIFY DNA BINDING SITE

摘要

METHOD OF DNA SEQUENCE REPRESENTATION BY USING DNA SURFACECHARGE PATTERNS AND ITS APPLICATION TO IDENTIFY DNA BINDINGSITEABSTRACTThe present invention provides a DNA sequence represented by a sequence ofsurface charge patterns. In one embodiment of the present invention, the DNA surface charge pattern sequence includes surface charge patterns of each single nucleotide base and di-nucleotides'; wherein the each single nucleotide base is selected from the group of A, T, G, and C; wherein the `di-nucleotides' is selected from the group of AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG and TT; and wherein the `di-nucleotides' are inserted into the inter-space between two adjacent nucleotide base and consist of the two nucleotide bases abutting the insertion point. The present invention also provides a method of DNA sequence representation by using surface charge patterns. The present invention further provides a method for identifying a DNA binding site by using the DNA sequences represented by a sequence of surface charge patterns.FIG 1