COMBINATION THERAPY OF ANGIOTENSIN-CONVERTING ENZYME-HEMMER AND EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

摘要

Combinations of an ACE inhibitor and an epoxy-steroidal aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using epoxy-steroidal-type aldosterone receptor antagonist compounds, such as eplerenone, in combination with an angiotensin converting enzyme inhibitor. This co-therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.