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METHOD FOR THE TREATMENT OF ILLNESSES BY CHANGING THE INTERACTION BETWEEN NATURAL KILLER RECEPTORS ON T CELLS WITH THEIR RESPECTIVE LIGANDS
METHOD FOR THE TREATMENT OF ILLNESSES BY CHANGING THE INTERACTION BETWEEN NATURAL KILLER RECEPTORS ON T CELLS WITH THEIR RESPECTIVE LIGANDS
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机译:通过改变自然杀手受体与相应配体在T细胞上的相互作用来治疗疾病的方法
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摘要
Methods of treating psoriasis and other cutaneous and extracutaneous disorders mediated by immunocytes bearing natural killer-type receptors (NK-T cells) for classical or non-classical MHC-class I-like molecules (and their functional homologs). The methods of the present invention include antagonizing the activation mediated by NK-type receptors for those diseases in which such immunocytes are causing or exarcebating the disease, as well as for methods to augment the immune response in infectious (viral, bacterial, or fungal) or neoplastic conditions in which such activation would be beneficial.
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