Protein Gene of ribosome inactivator of Leaves of Sambucus nigra L. called Nigrina 1 and Applications used in the therapy of Cancer and AIDS, and in the production of Plants resistant to fungal and Plant viruses fitopatogenicos.

摘要

Ribosome inactivating Protein Gene of Leaves of Sambucus nigra L. called Nigrina 1, Process for its production and Applications used in the therapy of Cancer and AIDS, and in the production of Plants resistant to virus fitopatogu00e9nicos mushrooms and Vegetables.We describe a procedure for obtaining the Nucleotide sequence and the sequence encoding the inactivator Protein of ribosomes present in the plant Nigrina 1 Sambucus nigra L. is the procedure and polinucleotu00eddica or Gene sequence and its Applications.The more immediate applications of the procedure are: 1) production in microorganisms and Plants the Nigrina 1 or part of the Nigrina 1 gene expression of Nigrina 1 or part of the Nigrina Gene 1; 2) production in microorganisms and plants conteniend fusion protein Or Nigrina 1 or part of the Nigrina 1 and a Peptide or Protein that directs the fusion protein to whiteSpecific human Therapy in particular cancer and AIDS; (3) the production of fusion proteins containing the Nigrina 1 or its chain and a Peptide or Protein that directs the fusion protein to specific targets for Increasing the Resistance of Plants to the ENFE Rmedades fitopatogu00e9nicos caused by fungi and viruses vu00e9getales; 4) the Construction of Plants containing theThe Nigrina 1 gene or its chain and are resistant to fungal and Plant Viruses fitopatogu00e9nicos; 5) the production of Nigrina 1 or its chain or its derivatives of larger and smaller size for Common applications of ribosome inactivating Proteins (rips) as toxic part The immunotoxins and Immunoconjugates as antiviral proteins and direct actionIn particular against the AIDS Virus (HIV) and antipatogu00e9nicos fitopatogu00e9nicos as agents against fungal and Plant viruses.